Tea polyphenols are the main components with health-care functions in tea.
Catechin is the main component of tea polyphenols.
EGCG is the main component of catechins.
It sounds a bit convoluted. Simply put, in a word, tea mainly depends on tea polyphenols, tea polyphenols mainly depends on catechins, and catechins mainly depends on EGCG. In other words, EGCG is the top priority.
So, What Are The Effects Of EGCG?
Modern medical research shows that the blood lipid-lowering effect of green tea is mainly due to the active ingredient epigallocatechin gallate (EGCG). EGCG has a regulatory effect on the metabolism of cholesterol, triglycerides and high-density lipoprotein. The regulation of blood lipid indexes can be achieved through multiple channels.
①EGCG can inhibit the synthesis of cholesterol by inhibiting the expression of the rate-limiting enzyme HMGCR for endogenous cholesterol production.
②Under the condition of a high-fat diet, EGCG can inhibit the reabsorption of bile acids by adsorbing with bile acids, thereby enhancing the conversion of cholesterol to bile acids in the liver, thereby lowering cholesterol.
③EGCG can enhance the expression of SREBP-2, thereby increasing the uptake of cholesterol by hepatocytes, reducing the content of serum low-density lipoprotein cholesterol (LDL-C) in the body, thereby exerting the activity of lowering blood lipids.
④EGCG can increase the activity of lecithin cholesterol acyltransferase (LCAT), thereby promoting the maturation of high-density lipoprotein (HDL). HDL binds to HDL receptors on liver cell membranes and is taken up by liver cells. At the same time, cholesterol is used in this process It is used to synthesize bile acid or excrete it through bile, thereby accelerating the elimination of cholesterol in liver metabolism.
①EGCG can inhibit the action of pancreatic lipase, reduce the absorption of fatty acids and then inhibit the synthesis of triglycerides, thereby reducing the blood triglyceride content.
②EGCG can inhibit the activity of fatty acid synthase (FAS), thereby reducing the synthesis of triglycerides in fat cells and lowering the level of triglycerides;
③EGCG can increase the activity of liver lipase (HL), promote the decomposition of triglycerides in serum and liver, and reduce triglyceride levels.
Interpretation of EGCG’s New Features
Promote healing of diabetic wounds
EGCG can target to attenuate the early inflammatory response of macrophages.
The research results of the team of Professor Sheng Jun from Yunnan Agricultural University: The main components of tea polyphenols can effectively promote the healing of the skin wounds of diabetic mice by inhibiting the inflammation targets of diabetic wounds. This is the first natural monomer activity in the world to promote the healing of diabetic wounds. Element. The scientific research results provide a scientific basis for people to develop natural medicines that promote the healing of diabetic wounds.