Hyaluronic acid (HA) is a kind of large molecular polysaccharides widely distributed in the human body (to be exact, it is called “glycyaminoglycan”). It is transparent, lubricating, and has a large molecular weight, so it has a certain viscosity.In the human body, the main distribution parts include the eyeball, between collagen and elastic fibers in the dermis, articular cavity and so on, which have a lot of important physiological use.An adult weighing 70kg has about 45g of hyaluronic acid in his body, of which 15g is degraded daily, while new hyaluronic acid is synthesized to compensate for the loss.

Hyaluronic acid is closely related to the skin, especially in the dermis.We already know that the dermis must be full and plump in order for the skin to be firm and elastic.This state of the dermis depends on the composition of the “extracellular matrix” within it, namely, collagen and elastic fibers.Elastic fibers act like springs in a sofa, collagen fibers act like sponges for support, and glycomylaminoglycan (especially hyaluronic acid) combines with water to fill the gaps in these fibers, like the air in a sofa.However, with the increase of age, the water content in the dermis did not decrease, but the water in the binding state with glycosaminoglycan decreased — this is mainly due to the decrease of glycosaminoglycan (especially hyaluronic acid), which shows the importance of hyaluronic acid for the young skin.

Hyaluronic acid is also widely used in animals, so the earliest use of hyaluronic acid was extracted from animals, especially from the delicious comb. Because of the small amount, it was very expensive, and its application was limited to medical treatment.Later, researchers could produce hyaluronic acid industrially through bioengineering, so that the price could be reduced to the level of wide application, and it became the most classic and excellent moisturizing ingredient. Nowadays, it seems not too comfortable to add hyaluronic acid to skin care products without it.

Due to its good biocompatibility, hyaluronic acid is also made into injection fillers for micro-shaping, which can adjust facial contours, fill wrinkles and pits, and improve skin wrinkling.The rise of beauty therapy, especially the dot matrix injection of microneedles (that is, “water acupuncture”), has further expanded the use of hyaluronic acid in cosmetic dermatology.

However, in addition to the above skin care, medical beauty, many may not know: Studies in the last 10 years have shown that oral hyaluronic acid can be absorbed by the body and improve skin quality.

ok of The Ancient Medicine of Abel, 1500 BC.The Ayurvedic texts describe the aphrodisiac effects of the herb.In ancient Egypt, fenugreek was used to relieve labor pains and other types of abdominal pain.


Absorption of oral hyaluronic acid and its effect on improving skin

In the searchable international journal literature, the first study on oral hyaluronic acid absorption and distribution was a joint study conducted in Hungary, China, and the United States in 2008, which explored whether oral hyaluronic acid could be absorbed into mice and dogs.In 2014, Mariko Oe et al. carried out further research by feeding mice with c14-labeled hyaluronic acid, an isotope of carbon.Studies have shown that after feeding mice for 8 hours, the content of hyaluronic acid in the blood reaches its peak, and then it is distributed throughout the body, and then gradually decreases. After 24 and 96 hours of intake, the amount of hyaluronic acid in the skin is significantly higher than that in the blood, suggesting that oral intake of hyaluronic acid may migrate to the skin.

In 2016, Mamoru Kimura et al carried out a further study [5], suggesting that after the intake of hyaluronic acid, it was decomposed into oligosaccharides by bacteria in the large intestine, and then absorbed through the large intestine, entering the whole body, including the skin.Taken together, these studies confirm that:

After ingestion through the mouth, hyaluronic acid can be absorbed and enter the skin of animals.

So after eating hyaluronic acid through the mouth, whether to improve the skin what effect?Fortunately, researchers in Japan, Italy and Germany conducted three randomized controlled clinical studies in humans between 2017 and 2019, and found that eating hyaluronic acid also improves skin.



A brief description of these experiments follows.

In 2017, Mariko Oe et al. in Japan conducted a randomized controlled clinical study [6], suggesting that oral hyaluronic acid (including 2000D and 300,000d molecular weight) can reduce wrinkles and improve skin.Sixty Japanese men and women aged 22 to 59 with crow’s feet were randomly assigned to receive hyaluronic acid or placebo for 12 weeks at a dose of 120mg/ day for 2,000 days, 300,000 days, or 300,000 days.The results showed that the hyaluronic acid group had significantly higher skin furrow volume ratio, wrinkle area ratio, and wrinkle volume than the placebo group.After eight weeks, the 300,000 D group had significantly fewer wrinkles than the placebo group.After 12 weeks, skin brightness and softness were better in all groups than at the initial level.

In 2017, Gollner et al. from Germany conducted a study to evaluate the effect of a cascelled fermented organic nutritional supplement containing hyaluronic acid, vitamin C, biotin, copper and zinc on improving the skin, and found that the moisture content and elasticity of the skin of subjects were significantly increased, while the skin roughness and wrinkle depth were significantly reduced.The study recruited 20 women, ages 45 to 60, who took the product daily for 40 days.Skin was measured before the trial, at 20 and 40 days of use, for moisture content, elasticity, roughness and depth of wrinkles.


Sodium hyaluronate
Sodium hyaluronate

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