Silythistle, native to the Mediterranean region, has been used as a medicinal plant for nearly two thousand years and is still widely used as a very effective liver protection plant.It helps detoxify the liver and can be used to control chronic liver disease.Silythistle can activate the regeneration of liver protein, restore the activity of liver cells destroyed by alcohol and virus, can also eliminate free radicals, maintain the permeability of liver cell membrane, reduce the damage of toxin to liver, protect the long-term drinking liver injury and people suffering from acute and chronic hepatitis, fatty liver, cirrhosis and toxic liver damage.
In the 1960s, a scientist in Germany successfully extracted the active ingredient silymarin from silymarin.Silymarin, composed of three different isomers: silybin, silymarin and silymarin, is currently recognized as a natural active ingredient with liver protection.China’s 2005 edition of the “Chinese Pharmacopoeia” will be included in the silthistle.
Composition of the highest levels in milk thistle is silymarin, scavenging free radicals, lipid peroxidation, protect liver cell membrane, and promote was damage liver cell structure of DNA and protein synthesis and pharmacological activities such as anti fibrosis, metabolic toxic liver injury of acute or chronic hepatitis and liver cirrhosis has good curative effect, has been listed as a drug, is the world recognized curative effect of liver damage repair medicine.
Silymarin, a dihydroflavone alcohol compound, has the function of resisting liver poisoning, protecting liver cells, etc., and can be used as bile excretion agent.For acute, diffuse hepatitis, cirrhosis, metabolic toxic liver injury, gallstones and gallstones caused by recurrent pain and cholangitis and other hepatobiliary diseases have a good effect.
Silybin is mainly shown as an antioxidant in vivo, which can inhibit the production of free radicals and lipid superoxidation, thus protecting the liver.The water solubility of silybin is very poor, so the extraction method of silybin should adopt the method of plant fat solubility, but not the way of water solubility.Therefore, even if the milk thistle drink water will not have much effect.The biological tolerability of silythistle extract is so good that adults can take 13 grams a day without obvious toxic reactions.Silythistle extract has been used for many years in Europe as a major ingredient in drugs such as Legalon and Silimarit, mainly for detoxification of the liver and treatment of chronic hepatitis and cirrhosis of the liver. In China, relevant scholars have also done a lot of pharmacological and clinical studies on silymarin extract.Li Rongping et al. discussed the effect of silybin on hepatocyte dilatation and its mechanism in acute liver injury.The experimental results showed that silibinin could significantly reduce the activity of serum transaminase in rats with acute liver injury, and the degree of liver tissue injury and hepatocyte dilatation were reduced under microscope.Liu Sandu et al. observed the efficacy of silybin in the treatment of alcoholic fatty liver, and the experiment proved that silybin had better efficacy in the treatment of alcoholic fatty liver, and could improve liver function and reduce blood lipid.The total effective rate of the treatment group was 86.7%, and that of the control group was 46.7%. The effect was significantly better than that of the control group, with definite curative effect and safe application.
So,what are the functions of Milk thistle extract?
1. Liver protection and antioxidant effect
Silymarin can maintain the fluidity of cell membrane through anti-lipid peroxidation reaction, thus protecting liver cell membrane.It can also inhibit superoxide anion release of neutrophils to reduce hepatocyte injury caused by inflammatory cells.Other studies have shown that silybin can increase the expression of superoxide dismutase in lymphocytes of mice with chronic alcoholic liver disease, thus playing an antioxidant role.Moreover, it has also been reported that silybin can reduce the production of reactive oxygen species and malondialdehyde and other oxides.
2. Anti-liver fibrosis effect
A number of studies have confirmed that silymarin can realize the anti-fibrosis effect through antioxidant and direct inhibition of various cytokines on the activation of hepatic stellate cells.
3. Liver protection and lipid lowering effect
Experimental results in mice showed that silybin could reduce the content of triglyceride, serum TG and total cholesterol in liver.In addition, these animal experiments also showed varying degrees of improvement in liver pathology (e.g., adipogenesis, inflammation, and balloon-like hepatocytes) after silybin intervention.There have also been studies suggesting that the drug can reduce the weight of test animals.
4. Anti-inflammatory effects
Silybin exerts an anti-inflammatory effect by lowering levels of several pre-inflammatory cytokines, such as IL-8, IL-6, McP-1, and TNF-.This effect is achieved by inhibiting IKK- and p50, p65 activity, thereby inhibiting the NF- B action.
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