Herba houttuyniae has been used as a constituent of herval health care prescriptions for the treatment of inflammation, cancer,and other diseases. In the present study, we investigated the cellular effects of herba houttuyniae extract (HHE) and the signal pathways of HHE-induced apoptosis in HL-60 human promyelocytic leukemia cell line. HHE treatment caused apoptosis of cells as evidenced by discontinuous fragmentation of DNA, the loss of mitochondrial membrane potential, release of mitochondrial cytochrome c into the cytosol, activation of procaspase-9 and caspase-3, and proteolytic cleavage of poly(ADP-ribose) polymerase. Pretreatment of Ac-DEVD-CHO, caspase-3 specific inhibitor, or A, a mitochondrial permeability transition inhibitor, completely abolished HHE-induced DNA fragmentation.
1. Remove toxic heat, to promote the drainange of pus, and to relieve dysuria.
2. Cure Lung abscess with purulent expectoration;
3. Heat in the lung with cough and dyspnea;
4. Cure acute dysentery; acute urinary infection;
5. Relieves Carbuncles and sores.
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