Glutathione (GSH), synthesized by the liver, is a small tripeptide compound widely found in cells of the body, with the highest concentration in the liver.It is involved in the regulation of intracellular amino acid transport, glucose metabolism and DNA synthesis, and plays an important role in antagonizing exogenous poisons, oxygen free radical damage, regulating the immune function of the body, maintaining the structure and function of cell protein, and inhibiting cell apoptosis.As one of the most important antioxidants in human body, GSH can directly antagonize the toxicity of oxygen free radicals by supplying H+, remove superoxide ions and other free radicals in the body, and prevent liver cell damage. Therefore, sufficient GSH level in liver cells is a necessary condition to prevent liver cell necrosis.
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Added exogenous GSH can improve the level of intracellular GSH, thus to provide liver enzyme active sulphur, promote liver enzyme activities, maintain the normal metabolism of liver cells and cell membrane integrity, at the same time through neutralization, scavenging free radicals, improve the endogenous superoxide dismutase (sod), glutathione peroxidase, thus reduce the lipid peroxidation of the liver tissue damage.It can increase the stability of liver cell membrane and decrease the liver transaminase. Therefore, it is considered as the total hub of anti-free radical in the body. It can not only eliminate free radical, but also reduce other antioxidants for recycling.
GSH can protect the sulfhydryl group of the protein in the organism and maintain the normal biological activity of the protein. At the same time, it is the coenzyme and cogroup of a variety of enzymes. It has strong affinity and can bind to a variety of chemical substances and their metabolites, so GSH has a variety of biological functions.
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