Valeriana Officinalis L. belongs to the perennial plant of the Valeriana family, with more than 250 species in Eurasia, South America, and central North America. Valerian extract was first used as a sedative in northern Europe in the mid-18th century. In 1966, Thies and Funke first isolated the triesters of Valeriana officinalis from Valeriana officinalis extract, which is also the first IRIDOID ester obtained. The most popular herb in the West for improving sleep is Valerian extract. Researchers such as Stephen Bent have shown that Valerian extracts improve sleep quality by aggregating results from 370 papers, 16 Randomized controlled trial, and 1,093 patients. Researchers have found that Valerian extracts promote the secretion of Gaba (Gaba) in the cerebral CORTEX, which regulates nerve cells, reduces anxiety and plays a calming role. This may be because we have neurotransmitter in the brain, a type of neurotransmitter that promotes sedation.
Valerian root extract contains valeric acid, terpenoids and other chemical active components with obvious activation of Gabaa receptor (Gaba a receptor) , which can effectively inhibit rapid eye movement sleep and low frequency waves, promote rapid sleep. Studies have shown that Valerian extract can also improve sleep by mediating the inhibition of Gaba enzyme disruption, thereby increasing the availability of Gaba.
In sleep aid academia, reducing the “Hangover”, looking for no hangover raw materials or herbal medicine is the researchers’favorite direction, which Valerian extract is very popular, relatively thorough study of an herb. In a randomized, controlled, double blind study of 102 male and female volunteers, German expert Kuhlmann j found that a single or repeated evening dose of 600 mg of Valerian extract had no negative effects on wake up time, Wakefulness, and post breakfast mental focus.
Valeriana Officinalis is widely distributed in almost all countries where soils are more acidic. Valerian extract has been used in traditional medicine for 2,000 years to treat sleep disorders, anxiety, fatigue, epilepsy, epilepsy, and depression. The main component of the medicinal Valerian extract is Valerian acid, which contains hydroxyl and acetone derivatives. Valerian acid has been shown to have anti-anxiety, sedative and sleep-inducing effects in animal studies and clinical trials. Valeric acid suppresses Gaba, caused by catabolism enzymes, in the brain, thus producing a sedative effect. Gaba is the most important brain inhibitory neurotransmitter and plays a key role in the regulation and function of central nervous system. The sedative effect of Valerian extract was promoted by Gabaa receptor Β3 subunit.
The GABRB3 gene belongs to the Ligand-gated Ion Channel family, which encodes the Beta 3 subunit of the GABAA receptor. GABRB3 is also a receptor for Diazepam and other narcotic drugs, known as phenobarbital. Shaanxi Rainwood Biotech Co. , Ltd. . , Ltd. . In laboratory studies, Valerian extracts affect the presynaptic components of gabaergic neurons, which affect the release of Gaba from synapses. Valerian extract also inhibits Gaba reuptake and catabolism by inhibiting Gaba. On this basis, Gabrb3 Mrna expression was significantly increased after Valeriana officinalis extract treatment. According to the Roller Test, Valerian extract and Diazepam have similar clinical sedative effect. Higher Doses of Valerian extract did not produce higher levels of Gabrb3 Mrna expression, nor did they produce a sedative effect.