| Product Name | Spermine Tetrahydrochloride Powder |
| Grade | Food Grade |
| Certification | HACCP/ISO 22000/HALAL/IS0 9001 |
| Specification | 99%Pure |
| Appearance | White powder |
| Delivery Time | 7 days |
| Nutrient Content | Vegan, Gluten-Free, Non-GMO, Natural |
| Shelf Life | 2 Years |
| Storage | Cool Dry Place |
This compound is widely utilized in biochemical research, nutraceuticals, and pharmaceutical applications due to its ability to modulate NMDA receptor activity, inhibit neuronal nitric oxide synthase (nNOS), and support cellular longevity37. It is highly soluble in water (≥100 mg/mL), making it suitable for in vitro and in vivo studies, as well as formulations in supplements and functional foods.
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Potent Biological Activity as a Higher-order Polyamine
Enhanced Autophagy Regulation: Studies show spermine may induce more robust autophagy (cellular waste clearance) than spermidine, particularly in age-related diseases like neurodegeneration and cancer.
DNA/RNA Stability Support: Binds to nucleic acids, protecting genetic material from oxidative damage and supporting telomere maintenance.
Enzyme Modulation: Regulates histone deacetylases (e.g., SIRT1) and polyamine oxidases, influencing epigenetic aging pathways.
Synergistic Effects with Spermidine: Often found together in cells, spermine complements spermidine’s functions, making it a valuable standalone or combinatorial ingredient.
Superior Chemical Properties for Formulation
Exceptional Solubility: Highly water-soluble, enabling clear solutions in beverages, injectables, or topical formulations without precipitation.
Thermal & pH Stability: Maintains integrity under manufacturing conditions (e.g., heat-press tablet production, acidic drinks), outperforming free-base spermine.
Precise Dosing: Pure crystalline structure (≥98% purity) allows standardized formulations, unlike natural sources (e.g., animal tissues, fermented foods) with variable spermine content.
Low Toxicity Profile: GRAS-notified in certain applications, with animal studies showing no adverse effects at physiologically relevant doses.
Emerging Clinical Evidence for Diverse Health Applications
Cardiovascular Health: Reduces arterial stiffness and improves endothelial function in human trials, potentially via nitric oxide modulation.
Skin Rejuvenation: Topical use enhances collagen synthesis and reduces wrinkle formation, with clinical data supporting its inclusion in anti-aging cosmetics.
Renal Protection: Mitigates kidney injury in preclinical models by inhibiting oxidative stress and inflammation.
Longevity Mechanisms: Extends lifespan in C. elegans and Drosophila by activating stress-response pathways, paralleling spermidine’s effects but with unique signaling dynamics.
Formulation Versatility Across Industries
Nutraceuticals: Standalone capsules (20–100 mg/day), anti-aging blends (with spermidine, NMN, resveratrol), or nootropic formulations for cognitive support.
Functional Foods & Beverages: Clear, odorless addition to sports drinks (for muscle recovery), eldercare nutrition (to combat sarcopenia), or gourmet products targeting longevity.
Cosmeceuticals: Serums, masks, or creams for topical anti-aging, often combined with peptides or hyaluronic acid for synergistic effects.
Veterinary Applications: Emerging use in pet supplements for joint health and senior pet vitality, tapping into the $30B global pet wellness market.
Strategic Market Positioning in Niche Longevity Segments
Premium Anti-Aging Market: Targets consumers willing to pay a premium for "next-generation" polyamines, positioning spermine as a more potent alternative to spermidine.
Scientifically-Driven Brands: Aligns with brands emphasizing mechanism-based ingredients (e.g., autophagy, DNA repair), differentiating from generic antioxidants.
Athletic Performance & Recovery: Leverages its role in muscle protein synthesis and cellular repair for post-workout supplements, competing with BCAAs and creatine.
Men’s Health: Potential use in prostate health supplements, as spermine levels correlate with prostate function in observational studies.
Established in 2006, we are a certified OEM/ODM manufacturer specializing in premium health supplements. Holding NSF-GMP,HACCP, ISO 22000, USDA Organic, EU Organic, Halal, and FDA certifications, our facility integrates advanced technologies for tablet, capsule, powder, gummy, and softgel production. From formulation to packaging, we provide full-cycle solutions with strict quality protocols, including raw material traceability, third-party lab testing, and Halal-compliant dedicated lines. Serving global markets including North America, Europe, and Asia, we prioritize sustainability through eco-friendly processes and transparent labeling. With 19+ years of expertise, we empower brands to deliver scientifically validated, certification-backed nutraceuticals tailored to diverse regulatory and cultural requirements 
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