| Product Name | Vitamin K2（MK-4) Powder |
| Grade | Food Grade |
| Certification | HACCP/ISO 22000/HALAL/IS0 9001 |
| Specification | 99%Pure |
| Appearance | Light Yellow Powder |
| Delivery Time | 7 days |
| Nutrient Content | Vegan, Gluten-Free, Non-GMO, Natural |
| Shelf Life | 2 Years |
| Storage | Cool Dry Place |
Vitamin K2 (MK-4) Powder is a highly bioactive form of vitamin K₂, specifically as menaquinone-4 (MK-4), the most rapidly absorbed and utilized variant in human metabolism. This premium-grade nutrient plays a critical role in calcium metabolism, directing calcium to bones and teeth while preventing arterial calcification—supporting both cardiovascular health and bone density.
|
Sulbutiamine Powder |
Urolithin A Powder |
|
DL-α-Tocopherol Powder |
Mecobalamin Powder |
|
Uridine / Uridinato Powder |
PQQ Powder |
Targeted Biological Activity for Bone & Cardiovascular Health
Bone Metabolism Regulation: MK-4 (menaquinone-4) is a key cofactor for γ-glutamyl carboxylase, activating osteocalcin (a bone protein) to bind calcium and promote bone mineralization. This targets osteoporosis and fractures more effectively than vitamin K1 (phylloquinone), which has limited skeletal efficacy.
Vascular Calcification Prevention: Activates matrix GLA protein (MGP) to inhibit calcium deposition in arterial walls, directly addressing cardiovascular risks associated with calcified plaques. Clinical studies show MK-4 may slow aortic calcification progression in postmenopausal women and dialysis patients.
Superior Bioavailability & Tissue Distribution
Rapid Absorption: As a lipid-soluble vitamin, MK-4 is efficiently absorbed via the lymphatic system, reaching peak plasma concentrations within 2–4 hours. Its short side chain (4 isoprene units) allows better penetration into bone, arterial, and brain tissues compared to long-chain MK-7.
Targeted Uptake: Enriched in osteoblasts (bone-forming cells) and vascular smooth muscle cells, enabling localized action where calcium regulation is critical. This contrasts with K1, which primarily accumulates in the liver.
Synthetic Purity & Formulation Stability
Consistent Potency: Industrial synthesis (e.g., from menadione) ensures high purity and standardized MK-4 content, eliminating batch-to-batch variability seen in natural sources (e.g., fermented foods).
Thermal & Oxidative Resistance: MK-4 powder maintains stability under controlled storage (cool, dark, dry), making it suitable for heat-processing in supplements (tablets, capsules) and fortified foods (dairy, snacks). Its esterified forms (e.g., MK-4 acetate) further enhance shelf-life in oil-based formulations.
Clinical Evidence & Regulatory Recognition
Established Efficacy: Approved in Japan since the 1980s as a therapeutic for osteoporosis (under the name "menaquinone-4"), with meta-analyses showing reduced vertebral fracture risk by 60–80% in postmenopausal women.
Global Safety Approvals: Recognized as GRAS by FDA for food fortification, and listed in the EU’s Novel Foods Catalogue for bone health claims. Its clear mechanism of action supports regulatory submissions for health claims in dietary supplements.
Versatility in Functional Formulations
Multi-Nutrient Synergy: Pairs effectively with vitamin D3, calcium, and magnesium to optimize bone health, as D3 enhances MK-4 activation of osteocalcin. This synergy drives demand in senior nutrition and preventive healthcare products.
Niche Applications: Used in dental care supplements to reduce periodontal calcification, and in veterinary medicine for equine bone health (e.g., treating navicular syndrome in horses).
Cosmetic Potential: Topical MK-4 may improve skin elasticity by inhibiting matrix metalloproteinases (MMPs), though research is ongoing.
Established in 2006, we are a certified OEM/ODM manufacturer specializing in premium health supplements. Holding NSF-GMP,HACCP, ISO 22000, USDA Organic, EU Organic, Halal, and FDA certifications, our facility integrates advanced technologies for tablet, capsule, powder, gummy, and softgel production. From formulation to packaging, we provide full-cycle solutions with strict quality protocols, including raw material traceability, third-party lab testing, and Halal-compliant dedicated lines. Serving global markets including North America, Europe, and Asia, we prioritize sustainability through eco-friendly processes and transparent labeling. With 19+ years of expertise, we empower brands to deliver scientifically validated, certification-backed nutraceuticals tailored to diverse regulatory and cultural requirements 
EN
