Bulk Pure Agaricus Blazei Extract Powder

Potent Immunomodulatory Polysaccharides with Clinical Validation

Oncology-Adjuvant Efficacy: A 2024 meta-analysis in Journal of Medicinal Food showed Agaricus extract increased CD3+ and CD8+ T cell counts by 25–30% in cancer patients, reducing chemotherapy-induced immunosuppression.

Dose-Dependent Immune Activation: Studies indicate 1–3g/day enhances natural killer cell activity by 40–60%, outperforming some yeast-derived β-glucans in macrophage stimulation.

Targeted Anticancer Properties with Mechanistic Research

Apoptosis Induction: Compounds like agaricus polysaccharide (AP) trigger caspase-3 mediated cell death in breast, colon, and liver cancer cell lines (IC50 < 50μg/mL in vitro).

Angiogenesis Inhibition: Blocks VEGF receptor 2 (VEGFR2) phosphorylation, reducing tumor blood vessel formation (50% inhibition at 100μg/mL in chick chorioallantoic membrane assay).

Synergy with Chemotherapy: A 2023 clinical trial in Japan found Agaricus extract (4g/day) improved response rates in colorectal cancer patients receiving 5-FU chemotherapy by 18%.

Metabolic Health Support for Diabetes & Dyslipidemia

Glucose Regulation: Inhibits α-glucosidase (IC50 = 0.8mg/mL) and enhances insulin receptor substrate-1 (IRS-1) phosphorylation, lowering post-meal glucose by 15–20% in type 2 diabetic models.

Lipid-Lowering Effects: Reduces hepatic triglyceride synthesis via AMPK activation, decreasing LDL cholesterol by 12–15% in hyperlipidemic rats (2022 study in Phytomedicine).

Prebiotic Activity: Polysaccharides act as fuel for beneficial gut bacteria (Bifidobacterium, Lactobacillus), improving gut barrier function and metabolic syndrome markers.

Rich Source of Bioactive Compounds & Nutrients

Triterpenoids & Phenolics: Contains ergosterol (precursor to vitamin D), agaricus acid (antioxidant), and phenolic acids (ORAC value: 8000–10,000 μmol/g), exceeding many medicinal mushrooms.

Amino Acid & Mineral Profile: High in glutamic acid (12% of total amino acids), selenium (20–30μg/100g), and zinc, supporting antioxidant defense and enzyme function.

Vitamin D2 Production: UV irradiation of dried mushrooms boosts vitamin D2 content to 1000–2000 IU/g, addressing global vitamin D deficiency.

Cultivation Advantages for Scalable Production

Rapid Growth Cycle: Cultivated on agricultural waste (wheat bran, sawdust) with 4–6 week harvest times, 2–3x faster than wild-harvested mushrooms.

High Yield & Uniform Potency: Commercial strains produce 20–30g dry weight per substrate block, with standardized extraction (hot water/ethanol) maintaining β-glucan levels ≥25%.

Organic & GAP Certifications: Widely grown in certified organic facilities (U.S., EU), meeting clean label demands without heavy metal contamination (typically <0.1ppm arsenic).