| Product Name | 5-Aminolevulinic Acid Powder |
| Grade | Food Grade |
| Certification | HACCP/ISO 22000/HALAL/IS0 9001 |
| Specification | 99%Pure |
| Appearance | Light Yellow Powder |
| Delivery Time | 7 days |
| Nutrient Content | Vegan, Gluten-Free, Non-GMO, Natural |
| Shelf Life | 2 Years |
| Storage | Cool Dry Place |
5-Aminolevulinic Acid (5-ALA) is a high-purity (≥98%) white to off-white crystalline powder with the molecular formula C₅H₉NO₃ and a molecular weight of 131.13 g/mol. As a key intermediate in the heme biosynthesis pathway, 5-ALA serves as the universal precursor for tetrapyrroles, including heme, chlorophyll, and cytochrome proteins, playing a vital role in cellular energy metabolism and mitochondrial function.
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Endogenous Metabolic Role and Natural Origin
As a non-proteinogenic amino acid and the rate-limiting precursor in heme biosynthesis, 5-ALA offers:
Biological Essentiality: Required for chlorophyll production in plants and heme synthesis in humans, making it a cornerstone of energy metabolism and cellular function .
GRAS Status: Generally Recognized As Safe (GRAS) by the FDA for use in dietary supplements and functional foods, enabling seamless market entry in regulated regions .
Natural Availability: Produced via fermentation (e.g., by photosynthetic bacteria) or chemical synthesis, aligning with clean-label and sustainability trends.
Superior Biochemical Properties
pH-Dependent Solubility: Soluble in water (100 g/L at pH 7.4) and organic solvents, facilitating diverse formulations .
Enzymatic Activation: Converted intracellularly to PpIX, ensuring targeted action with minimal systemic toxicity .
Stability Tradeoffs: While the free acid form is less stable than derivatives like 5-ALA hydrochloride, it offers cost advantages and direct bioavailability in applications requiring rapid activation .
Regulatory Compliance and Safety
Global Approvals:
FDA-approved for optical imaging in glioma surgery (as hydrochloride salt) .
EU-approved for PDT in actinic keratosis and skin cancers .
Kosher/Halal-certified via chemical synthesis (no animal-derived components) .
Low Toxicity: Oral LD₅₀ >2 g/kg in rodents, with minimal skin irritation .
Cost-Effectiveness and Scalable Production
Efficient Manufacturing: Industrial production via fermentation or chemical synthesis yields ≥98% purity at costs 30–50% lower than premium PDT precursors .
Dosage Efficiency: Lower application rates (10–20 g/ha in agriculture vs. 50–100 g/ha for 5-ALA hydrochloride) due to direct bioactivity .
Economies of Scale: Annual production capacities exceeding 500 tons, with bulk pricing at $12–$200/kg vs. $300–$400/kg for specialized derivatives .
Established in 2006, we are a certified OEM/ODM manufacturer specializing in premium health supplements. Holding NSF-GMP,HACCP, ISO 22000, USDA Organic, EU Organic, Halal, and FDA certifications, our facility integrates advanced technologies for tablet, capsule, powder, gummy, and softgel production. From formulation to packaging, we provide full-cycle solutions with strict quality protocols, including raw material traceability, third-party lab testing, and Halal-compliant dedicated lines. Serving global markets including North America, Europe, and Asia, we prioritize sustainability through eco-friendly processes and transparent labeling. With 19+ years of expertise, we empower brands to deliver scientifically validated, certification-backed nutraceuticals tailored to diverse regulatory and cultural requirements 
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