| Product Name | Chitosan Quaternary Ammonium Salt Powder |
| Grade | Food Grade |
| Certification | HACCP/ISO 22000/HALAL/IS0 9001 |
| Specification | 99%Pure |
| Appearance | White powder |
| Delivery Time | 7 days |
| Nutrient Content | Vegan, Gluten-Free, Non-GMO, Natural |
| Shelf Life | 2 Years |
| Storage | Cool Dry Place |
Chitosan Quaternary Ammonium Salt Powder is a high-performance, water-soluble cationic derivative of chitosan, produced through quaternization modification. This advanced biopolymer exhibits enhanced solubility, stronger antibacterial properties, and improved film-forming capabilities compared to standard chitosan.
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Enhanced Water Solubility & pH-Independent Charge Density
Chitosan quaternary ammonium salt (CQAS) is synthesized by grafting quaternary ammonium groups (e.g., 2-hydroxypropyltrimethylammonium chloride) onto chitosan’s glucosamine units. This modification overcomes chitosan’s inherent limitation:
Broad pH Solubility: While native chitosan dissolves only at pH < 6.5, CQAS remains soluble in neutral/alkaline media (pH 7–10) due to permanent positive charges (pKa > 12). For example:
CQAS with 60% degree of quaternization (DQ) dissolves at pH 8.5 with a viscosity of 300–500 cP, enabling applications in alkaline solutions (e.g., detergent formulations).
Consistent Charge Density: Unlike chitosan, whose cationic charge decreases at high pH, CQAS maintains full charge (ζ-potential +25 to +35 mV at pH 7), enhancing:Adhesion to anionic surfaces (e.g., hair, fabrics) for cosmetics and textiles.
Interaction with anionic biomolecules (DNA, mucin) in biomedical applications.
Potentiated Antimicrobial Activity & Mechanistic Versatility
CQAS exhibits 2–10x higher antimicrobial efficacy than native chitosan against:
Bacteria: Inhibits E. coli (MIC 50–100 μg/mL) and S. aureus (MIC 25–50 μg/mL) via:Disruption of bacterial membranes (lipid bilayer permeabilization).
Inhibition of biofilm formation (reduces Pseudomonas aeruginosa biofilm by 90% at 0.1% w/v).
Fungi & Viruses: Effective against Candida albicans (MIC 100–200 μg/mL) and enveloped viruses (e.g., herpes simplex, inactivation rate >99% within 30 min).
Synergistic Effects: CQAS enhances the activity of conventional antimicrobials:Combinations with tea tree oil reduce MIC of both components by 50%.
Alignment with Emerging Industry Trends
Antimicrobial Resistance (AMR) Solutions: CQAS’s multi-mechanistic action (membrane disruption + metabolic inhibition) lowers resistance development risk vs. single-target antibiotics.
Eco-Friendly Disinfectants: Biodegradable CQAS (half-life in seawater 21 days) replaces persistent quaternary ammonium compounds (e.g., cetrimonium bromide) in marine applications.
Personalized Healthcare: pH-responsive CQAS hydrogels for on-demand drug release (e.g., tumor-targeted delivery of doxorubicin, release rate increases 4x at pH 6.0 vs. pH 7.4).
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